crispri

Reproducible CRISPRi/Perturb-seq analysis of an ENTPD1/CD39 T-cell program in rheumatoid arthritis and methotrexate treatment

Repository containing the code and methods for Bosch & DeJesus et al. 2021

🌱 Designing CRISPRi experiments in bacteria

PyTorch classifier predicting CRISPRi guide identity from single-cell expression (Adamson et al. 2016 Perturb-seq)

Phenotypic screening of a CRISPRi strain library [Smith et 2017, Mol Syst Biol (2017)13:913] for acetic acid tolerance targeting essential and respiratory essential genes in Saccharomyces cerevisiae

AI-assisted platform for designing CRISPR experiments — from target selection to bench-ready protocols

Adversarial-debate LLM agent for predicting CRISPRi perturbation effects on gene expression (Genentech MLGenX BioReasoning Challenge)

Figure code and data for Johnson et al. 2021, J Am Chem Soc 143(31):12003-12013, doi:10.1021/jacs.1c02622. CRISPRi chemical genomics identifying IleRS as the target of thiomarinol

Computational design and adversarial validation of synthetic gene circuits targeting PDAC transcription factors, trained from scratch on real public genomics data