BoltzGen: Toward Universal Binder Design

The Rosetta Bio-macromolecule modeling package. Available through license with the University of Washington.

Improved antibody structure-based design using inverse folding

This repo contains the codes for our paper "End-to-End Full-Atom Antibody Design"

This repo contains the codes for our paper Conditional Antibody Design as 3D Equivariant Graph Translation.

The official implementation of DiffAbXL benchmarked in the paper "Exploring Log-Likelihood Scores for Ranking Antibody Sequence Designs", formerly titled "Benchmarking Generative Models for Antibody Design".

Codes for our paper "UniMoMo: Unified Generative Modeling of 3D Molecules for De Novo Binder Design" (ICML 2025)

AI-powered biologics design campaign agent — multi-agent orchestration with BoltzGen, PXDesign, Protenix, and 200+ cloud tools. Antibodies, nanobodies, de novo binders, and beyond.

Codes for our paper "Programming Biomolecular Interactions with All-Atom Generative Model"

This is the official repository of paper - GeoAB: Towards Realistic Antibody Design and Reliable Affinity Maturation (ICML2024)

An antibody-specific language model focusing on NGL prediction

structural antibody parser and database

Conditionally Site-Independent Neural Evolution of Antibody Sequences (ICML '26)

A Collection of Platform, Tools, and Resources for Antibody Engineering

Associated code/pipeline for the publication "AI-assisted protein design to rapidly convert antibody sequences to intrabodies targeting diverse peptides and histone modifications"

Propose CDR single-point mutations that rescue antibody expression without disrupting antigen binding, using bound vs. unbound ProteinMPNN logit analysis.

Protein design with infilling language models and reinforcement learning — for antibodies and beyond.

The official implementation of "Improving Antibody Humanness Prediction using Patent Data".

Code for ADIOS: Antibody Development via Opponent Shaping

Integer Linear Programming for Protein Library Design