TF-DISCO is an integrated database and visualization platform for transcription factors (TFs). It combines curated information from UniProt, DisProt, and the ELM Resource with precomputed disorder predictions from AIUPred, flDPnn, and Metapredict v3. TF-DISCO enables users to explore known functional motifs in sequence context, examine their distribution within DNA-binding and activation domains, identify shared motifs across TF sets, and investigate relationships between motif occurrence and intrinsic disorder.